Fact Check- Does Fasting/ Calorie Restriction Help in Prevention & Treatment of Cancers?

Fasting, intermittent fasting, calorie restriction, cancer and fasting, cancer prevention, cancer treatment, fasting effects on cancer, fasting-mimicking-diets

For the past few decades, many studies have been published showing that fasting or a fasting-mimicking diet(Intermittent fasting) can reduce risk factors for and reverse symptoms of serious health conditions including cancer.

Fact Check- Does Fasting/ Calorie Restriction Help in Prevention & Treatment of Cancers?

Overview

People fast (abstain from food or drink) for a variety of reasons. Some fast to prepare for a medical procedure or blood test. Others for religious reasons. And the hottest diet trend these days is intermittent fasting, a weight-loss strategy that focuses more on when you eat rather than what you eat.

Also Read: Is intermittent fasting safe after weight loss surgery?

You may also have heard that fasting reduces cancer risk or improves your ability to fight it. Could fasting-related changes to your metabolism really make a difference, either by hurting cancer cells or enhancing the effectiveness of cancer-fighting drugs?

While the studies in this field are limited, there have been clinical evidences that show the positive impact of fasting or calorie restriction on prevention and treatment of cancer.

Fasting & Calorie Restriction

What are they?

Calorie restriction means limiting the consumption of food, without resulting in malnutrition, to less than what an organism would eat if given free access. Fasting on the other hand is voluntarily not eating any food for varying lengths of time. Fasting has been used as a therapy for many different conditions as well as a part of spiritual/religious practices throughout history.

Calorie Restriction- 20-40% reduction in calorie intake over a long period of time (1200 calories for women vs 1400 calories for men per day)
Intermittent Calorie Restriction- 50-70% reduction in calorie intake for short periods of time (600-1000 calories per day)
Fasting- Complete avoidance of calorie intake for anywhere from 1 day to several weeks
Intermittent Fasting- Complete avoidance of calorie intake for 16-18 hours daily or alternating a fasting day with a normal energy intake day

How do they work?

Your body is designed to protect you against starvation. To do this, it stores a reserve of the nutrients needed to survive when you eat.

When you’re not eating normally, this puts the cells under mild stress, and your body begins to release those stores to fuel itself. Experts suggest that as long as your body has time to heal itself after this period of stress, you won’t experience negative effects.(Source)

One of the most immediate results of this type of diet is weight loss, since your body is using more calories than it’s taking in.

It’s important to be careful about fasting/ calorie restriction for an extended period of time that your body cannot handle. Complete or continuous fasting will trigger “starvation mode,” in which your body starts slowing down to prolong your life. This typically begins after three days of continuous fasting. During this fasting period of more than three days, your body will hold on to fuel stores as much as possible, and you won’t notice weight loss.

The science behind fasting and cancer- what Research says

Weight loss is just one benefit of fasting for a normal healthy (disease-free) adult. Recent animal studies and a few preliminary human trials have shown a decrease in risk for cancer or a decrease in cancer growth rates. These studies indicate this may be due to the following effects from fasting:

Decreased blood glucose production
Stem cells triggered to regenerate the immune system
Balanced nutritional intake
Increased production of tumor-killing cells

In one study of time-restricted feeding during 9–12 hour phases, fasting was shown to reverse the progression of obesity and type 2 diabetes in mice. Obesity is a major risk factor for cancer, which may support fasting to treat cancer.

A second study of mice showed that a bimonthly fasting-mimicking diet reduced the incidence of cancer. Results were similar in a pilot trial by the same scientists with 19 humans; it showed decreased biomarkers and risk factors for cancer.

In a 2016 study, research showed that a combination of fasting and chemotherapy slowed the progression of breast cancer and skin cancer. The combined treatment methods caused the body to produce higher levels of common lymphoid progenitor cells (CLPs) and tumor-infiltrating lymphocytes. CLPs are the precursor cells to lymphocytes, which are white blood cells that migrate into a tumor and are known for killing tumors.

The same study noted short-term starvation makes cancer cells sensitive to chemotherapy while protecting normal cells, and it also promoted the production of stem cells.

Also Read: New hope for cure of type 1 diabetes by stem cell therapy

Another study suggested that a combination of fasting or fasting-mimicking-diet with chemotherapy, immunotherapy or other treatments show a potentially promising strategy to increase cancer treatment efficacy, prevent resistance acquisition and reduce side effects.

What to keep in mind while fasting as a method of prevention/ treatment of cancer?

Cancer patients who plan to fast should first consult their oncologist or care team. Fasting may not be appropriate for malnourished individuals or those with cancer cachexia, which results in a continuing loss of skeletal muscle mass, or for people with chronic diseases. Those with diabetes need to be very careful, because of the risk of hypoglycemia(low blood sugar, the body's main source of energy).

Fasting also is not recommended for people with a history of eating disorders, including anorexia nervosa and bulimia, or for those with wounds that need adequate nutrition to heal.

For any health related query, consult with our experts-

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Reference

This Article is authored by

Dr Avinash Tank (Mch) (Gastroenterologist)

Published on : 8th August 2022

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Australia cricket legend and the greatest leg-spinner of all-time, Shane Warne passed away at the age of 52. Warne’s management released a brief statement stating that he passed away in Thailand of a suspected heart attack.

World Obesity Day 2022: Learn about the health risks of Obesity and how we can beat them

World Obesity Day is observed annually on March 4 to create awareness about the disease, which has become a global epidemic that affects billions of people around the world.

Experts predict 4th wave of COVID-19 in India

A recently posted study by IIT- K researchers suggests a possible new COVID-19 wave to hit around the end of June ‘22 and last upto 4 months.

New Guidelines for Diabetes Treatment issued by American Diabetes Association 2022

Learn about the latest clinical practice standards to diagnose and manage diabetes in the American Diabetes Association’s (ADAs) 2022 Standards of Medical Care in Diabetes.

Indian Music composer and singer Bappi Lahiri dies due to obstructive sleep apnea a complication of untreated obesity

Indian Music composer and singer Bappi Lahiri dies due to obstructive sleep apnea, a complication of untreated obesity

Best hernia specialist doctor and hospital in Ahmedabad Gujarat

With an experienced team of doctors and a world class facility, here is how we can help you with Hernia.

Hernia Treatment cost in India

Hernia surgery is also known as Hernia repair surgery. It is a surgical procedure which involves either placing the displaced tissues back to their original position or a mesh over the weak region of the muscle.

GERD Recovery from Surgery and Live testimonial

Here is all you need to know about stages of recovery after GERD Treatment.

GERD Preparation of Surgery

In some cases, a doctor might suggest his patient undergo surgery for treating GERD. Here is what you should know.

Case Study 12 Year old gets surgery for pancreas after getting hit with a bicycle handle

Here is a case study of one of our recent patients in an effort to share our experience with healthcare providers and with patients who may benefit.

Use of Antibiotic linked with increased risk of colon cancer

Prolonged use of Antibiotic may increase the risk of colon cancer as confirmed by researchers at Umeå University, Sweden. Here is how-

Overeating may not be the only cause of obesity the Carbohydrate Insulin Model can better determine causes research claims

Real Life Tarzan who lived in the jungles for 41 years dies of liver cancer

Real Life Tarzan, who lived in the jungles for 41 years, dies of liver cancer. Here's how modern day city lifestyle may lead to heath hazards.

4 ways how recent Covid 19 restrictions can disrupt economic recovery

Several states including Maharashtra have imposed partial lockdowns due to a sharp rise in new Covid-19 cases. If these curbs get stricter, India's economic recovery could face serious roadblocks. Here's why.

Gallstones treatment cost in India

Find out Gallstones treatment cost in 15 major cities of India here.

Gallstones Recovery from Surgery and live testimonial

If you experience persistent and severe abdominal pain from gallstones, your doctor may recommend to have your gall bladder removed.

Snooze to Lose The Sleep and Weight Loss Connection

Learn how sleeping adequate amount can assist in gaining healthy weight.

How to Avoid Falling into Old Habits after Weight-Loss Surgery

Tips & tricks to avoid falling into old habits after obesity surgery.

Know about India's Covid 19 vaccines Covishield and Covaxin

Living as a Stomach Cancer Survivor

A patient shares his experience of successful stomach cancer treatment and adjusting to his new 'normal' life

Life after Stomach cancer for survivors

Life after stomach cancer means returning to some familiar things and making some new choices.

Stomach Cancer Screening for self and family Tests and Guidelines

Screening is testing for a disease, such as cancer, in people without symptoms. Here is a guide on how it is done.

Stomach Cancer Prognosis and Life Expectancy

Survival rates may help give you a better understanding of how likely it is that your treatment will be successful.

Stomach Cancer Treatment Surgery Chemotherapy Radiation and Biologicals

Learn about the different types of treatments doctors use for people diagnosed with stomach cancer.

Stomach Cancer Diagnosis and Staging

Learn about the diagnosis and staging of stomach cancer.

Colon Rectum Cancer Postoperative Recovery and Care

Know about Colon-Rectum Cancer Postoperative Recovery and Care

Vyapaar Jagat awards Dr. Avinash Tank (Dwarika Clinic) as Obesity Doctor of the year 2020

Vyapaar Jagat awards Dr. Avinash Tank (Dwarika Clinic) as Obesity Doctor of the year 2020 in their annual awards and recognition function.

Bariatric Surgery now covered under insurance in India- Know all the details

Bariatric Surgery is now covered under health insurance in India. Here is all that you need to know.

What Foods and Drinks Should You Avoid After Bariatric Surgery

Check out this article to find out the foods and drinks to avoid after Bariatric Surgery.

Cost of Colon-Rectum Cancer treatment in India

Read to find out what is the Cost of Rectal Cancer Treatment with Top Hospitals and Top Surgeons in India.

Living as a Colorectal Cancer Survivor

Learning to live after cancer treatment can be difficult and stressful. Here are things to know/ consider while living as a Colorectal Cancer Survivor.

Colon-Rectum Cancer- Things to know prior to surgery

Things you should know prior to Colon-Rectum Cancer surgery.

Colon-Rectum Cancer- Diagnosis & Staging

Eggs vs Paneer which is a better source of protein and beneficial for weight loss

Wondering whether Egg or Paneer can be a better source of protein and benefit your weight loss plan? Read to find out.

Diego Maradona's age-long battle against obesity

Know about Diego Maradona's age-long battle against obesity

6 Primary Causes of Obesity

Know about 6 Primary Causes of Obesity in children and adults.

CDC Says Virus Can Spread Indoors in Air Beyond Six Feet

Recent reports from CDC state that COVID-19 can spread indoors beyond 6 feet in enclosed spaces with poor ventilation. Read to find out more.

COVID-long haulers: People who have tested negative but continue to battle the symptoms

All you need to know about COVID-long haulers: People who have tested negative but continue to battle the symptoms.

Stomach Cramps After Eating: What It Could Mean

If your stomach hurts after eating, this could be why.

Childhood Obesity- Causes & Consequences

What are causes and consequences of Childhood Obesity?

3 ways to prevent stress eating

Here are 3 proven ways to prevent stress eating

Obesity now recognised as a â€œchronic diseaseâ€ by World Obesity Federation

Obesity is now recognised as a â€œchronic diseaseâ€ by World Obesity Federation. Read to find out more.

Is COVID 19 the same as SARS

There were several speculations whether COVID-19 was the same as SARS or MERS. While there are similarities between the illnesses, the differences are more substantial.

Best way to stay protected, Wear Masks