Ampullary Cancer- a rare kind of GI cancer

Ampullary Cancer

Ampullary cancer is a rare type of cancer that affects the ampulla of Vater in the gastrointestinal system.

What is Ampullary Cancer?

Ampullary cancer is a rare cancer that forms in an area of your digestive system called the ampulla of Vater. The ampulla of Vater is located where your bile duct and pancreatic duct join and empty into your small intestine.

Ampullary cancer forms near many other parts of the digestive system, such as the liver, pancreas and small intestine. When ampullary cancer grows, it may affect these other organs.

Ampullary cancer treatment often involves extensive surgery to remove the cancer and a large margin of healthy tissue.

Symptoms of Ampullary Cancer

Signs and symptoms of ampullary cancer may include:

Yellowing of the skin and eyes (jaundice)
Clay-colored stools
Abdominal pain
Fever
Bleeding from the rectum
Nausea & Vomiting
Weight loss

When to see a doctor

Make an appointment with your doctor if you have any persistent signs or symptoms that worry you.

Causes of Ampullary Cancer

It's not clear what causes ampullary cancer.

In general, cancer starts when cells develop changes (mutations) in their DNA. A cell's DNA contains the instructions that tell the cell what to do. The changes tell the cell to begin multiplying uncontrollably and to continue living when normal cells would die. The accumulating cells form a tumor that can invade and destroy normal body tissue.

Risk factors of Ampullary Cancer

Factors that can increase the risk of ampullary cancer include:

Your age. Ampullary cancer is more common in adults older than 70.
Being male. Males are slightly more likely to develop ampullary cancer than are females.
Inherited syndromes that increase cancer risk. Some gene mutations passed through generations of your family can increase your risk of ampullary cancer significantly. Only a small percentage of ampullary cancers are linked to inherited genes. The most common inherited syndromes that increase ampullary cancer risk are familial adenomatous polyposis and Lynch syndrome, which is also known as hereditary nonpolyposis colorectal cancer.

Diagnosis of Ampullary Cancer

Tests and procedures used to diagnose ampullary cancer include:

Passing a thin, flexible scope down your throat (endoscopy). Endoscopy is a procedure to examine your digestive system with a long, thin tube (endoscope) equipped with a tiny camera. The endoscope is passed down your throat, through your stomach and into your small intestine to view the ampulla of Vater.
Special surgical tools can be passed through the endoscope to collect a sample of suspicious tissue.
Endoscopy can also be used to create images. For instance, endoscopic ultrasound may help capture images of ampullary cancer.
Doctors may also inject a dye into your bile duct using endoscopy in a procedure called endoscopic retrograde cholangiopancreatography. The dye shows up on X-rays and can show blockages in your bile duct or pancreatic duct.
Imaging tests. Imaging tests may help your doctor understand more about your cancer and determine whether it has spread beyond the ampulla of Vater. Imaging tests may include endoscopic ultrasound, endoscopic retrograde cholangiopancreatography, magnetic resonance cholangiopancreatography and computerized tomography.
Testing cancer cells in the laboratory. A sample of cancer cells removed during endoscopy or surgery can be analyzed in the lab to look for characteristics that might guide treatment and prognosis.

Treatment of Ampullary Cancer

Ampullary cancer treatment options may include:

Surgery to remove the pancreas and small intestine. The Whipple procedure (pancreaticoduodenectomy) involves removing the head of your pancreas as well as a portion of your small intestine (duodenum), your gallbladder and part of your bile duct.
The Whipple procedure can be done using a large incision in your abdomen, or as a minimally invasive surgery, which uses several small incisions.
Minimally invasive surgery. For very small ampullary cancers and precancerous tumours, it may be possible to remove the cancer with tools passed through an endoscope (endoscopic surgery). This may be an option in certain situations.
Combined chemotherapy and radiation. Chemotherapy uses drugs to kill cancer cells. Radiation therapy uses beams of energy, such as X-rays and protons, to kill cancer cells. Used together, these treatments may be more effective for ampullary cancers.
Combined chemotherapy and radiation may be used before surgery, to make it more likely that a cancer can be removed completely during an operation. The combined treatment can also be used after surgery to kill any cancer cells that might remain.
Chemotherapy alone. Chemotherapy is sometimes used after surgery to kill cancer cells that might remain. In people with advanced ampullary cancer, chemotherapy may be used alone to slow the growth of the cancer.
Treatment to reduce pain and discomfort. If other treatments aren't possible or aren't helping, your doctor may recommend treatments that focus on making you feel more comfortable. This can include surgery to place a small wire mesh tube (stent) in your bile ducts to drain fluid that causes your skin and eyes to yellow.

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may allow time later to cover other points you want to address. Your doctor may ask:

When did you first begin experiencing symptoms?
Have your symptoms been continuous or occasional?
How severe are your symptoms?
What, if anything, seems to improve your symptoms?
What, if anything, appears to worsen your symptoms?

For any health related query, consult with our experts here-

Book a Consultation

Reference

This Article is authored by

Dr Avinash Tank (Mch) (Gastroenterologist)

Published on : 31st May 2022

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Those between 12-14 years of age will be administered the Corbevax manufactured by the Hyderabad-based pharma giant Biological E Limited, govt had stated.

Shane Warne, Australia cricket legend, dies of sudden heart arrest. Know more about sudden cardiac arrest.

Australia cricket legend and the greatest leg-spinner of all-time, Shane Warne passed away at the age of 52. Warne’s management released a brief statement stating that he passed away in Thailand of a suspected heart attack.

World Obesity Day 2022: Learn about the health risks of Obesity and how we can beat them

World Obesity Day is observed annually on March 4 to create awareness about the disease, which has become a global epidemic that affects billions of people around the world.

Experts predict 4th wave of COVID-19 in India

A recently posted study by IIT- K researchers suggests a possible new COVID-19 wave to hit around the end of June ‘22 and last upto 4 months.

New Guidelines for Diabetes Treatment issued by American Diabetes Association 2022

Learn about the latest clinical practice standards to diagnose and manage diabetes in the American Diabetes Association’s (ADAs) 2022 Standards of Medical Care in Diabetes.

Indian Music composer and singer Bappi Lahiri dies due to obstructive sleep apnea a complication of untreated obesity

Indian Music composer and singer Bappi Lahiri dies due to obstructive sleep apnea, a complication of untreated obesity

Best hernia specialist doctor and hospital in Ahmedabad Gujarat

With an experienced team of doctors and a world class facility, here is how we can help you with Hernia.

Hernia Treatment cost in India

Hernia surgery is also known as Hernia repair surgery. It is a surgical procedure which involves either placing the displaced tissues back to their original position or a mesh over the weak region of the muscle.

GERD Recovery from Surgery and Live testimonial

Here is all you need to know about stages of recovery after GERD Treatment.

GERD Preparation of Surgery

In some cases, a doctor might suggest his patient undergo surgery for treating GERD. Here is what you should know.

Case Study 12 Year old gets surgery for pancreas after getting hit with a bicycle handle

Here is a case study of one of our recent patients in an effort to share our experience with healthcare providers and with patients who may benefit.

Use of Antibiotic linked with increased risk of colon cancer

Prolonged use of Antibiotic may increase the risk of colon cancer as confirmed by researchers at Umeå University, Sweden. Here is how-

Overeating may not be the only cause of obesity the Carbohydrate Insulin Model can better determine causes research claims

Real Life Tarzan who lived in the jungles for 41 years dies of liver cancer

Real Life Tarzan, who lived in the jungles for 41 years, dies of liver cancer. Here's how modern day city lifestyle may lead to heath hazards.

4 ways how recent Covid 19 restrictions can disrupt economic recovery

Several states including Maharashtra have imposed partial lockdowns due to a sharp rise in new Covid-19 cases. If these curbs get stricter, India's economic recovery could face serious roadblocks. Here's why.

Gallstones treatment cost in India

Find out Gallstones treatment cost in 15 major cities of India here.

Gallstones Recovery from Surgery and live testimonial

If you experience persistent and severe abdominal pain from gallstones, your doctor may recommend to have your gall bladder removed.

Snooze to Lose The Sleep and Weight Loss Connection

Learn how sleeping adequate amount can assist in gaining healthy weight.

How to Avoid Falling into Old Habits after Weight-Loss Surgery

Tips & tricks to avoid falling into old habits after obesity surgery.

Know about India's Covid 19 vaccines Covishield and Covaxin

Living as a Stomach Cancer Survivor

A patient shares his experience of successful stomach cancer treatment and adjusting to his new 'normal' life

Life after Stomach cancer for survivors

Life after stomach cancer means returning to some familiar things and making some new choices.

Stomach Cancer Screening for self and family Tests and Guidelines

Screening is testing for a disease, such as cancer, in people without symptoms. Here is a guide on how it is done.

Stomach Cancer Prognosis and Life Expectancy

Survival rates may help give you a better understanding of how likely it is that your treatment will be successful.

Stomach Cancer Treatment Surgery Chemotherapy Radiation and Biologicals

Learn about the different types of treatments doctors use for people diagnosed with stomach cancer.

Stomach Cancer Diagnosis and Staging

Learn about the diagnosis and staging of stomach cancer.

Colon Rectum Cancer Postoperative Recovery and Care

Know about Colon-Rectum Cancer Postoperative Recovery and Care

Vyapaar Jagat awards Dr. Avinash Tank (Dwarika Clinic) as Obesity Doctor of the year 2020

Vyapaar Jagat awards Dr. Avinash Tank (Dwarika Clinic) as Obesity Doctor of the year 2020 in their annual awards and recognition function.

Bariatric Surgery now covered under insurance in India- Know all the details

Bariatric Surgery is now covered under health insurance in India. Here is all that you need to know.

What Foods and Drinks Should You Avoid After Bariatric Surgery

Check out this article to find out the foods and drinks to avoid after Bariatric Surgery.

Cost of Colon-Rectum Cancer treatment in India

Read to find out what is the Cost of Rectal Cancer Treatment with Top Hospitals and Top Surgeons in India.

Living as a Colorectal Cancer Survivor

Learning to live after cancer treatment can be difficult and stressful. Here are things to know/ consider while living as a Colorectal Cancer Survivor.

Colon-Rectum Cancer- Things to know prior to surgery

Things you should know prior to Colon-Rectum Cancer surgery.

Colon-Rectum Cancer- Diagnosis & Staging

Eggs vs Paneer which is a better source of protein and beneficial for weight loss

Wondering whether Egg or Paneer can be a better source of protein and benefit your weight loss plan? Read to find out.

Diego Maradona's age-long battle against obesity

Know about Diego Maradona's age-long battle against obesity

6 Primary Causes of Obesity

Know about 6 Primary Causes of Obesity in children and adults.

CDC Says Virus Can Spread Indoors in Air Beyond Six Feet

Recent reports from CDC state that COVID-19 can spread indoors beyond 6 feet in enclosed spaces with poor ventilation. Read to find out more.

COVID-long haulers: People who have tested negative but continue to battle the symptoms

All you need to know about COVID-long haulers: People who have tested negative but continue to battle the symptoms.

Stomach Cramps After Eating: What It Could Mean

If your stomach hurts after eating, this could be why.

Childhood Obesity- Causes & Consequences

What are causes and consequences of Childhood Obesity?

3 ways to prevent stress eating

Here are 3 proven ways to prevent stress eating

Obesity now recognised as a â€œchronic diseaseâ€ by World Obesity Federation

Obesity is now recognised as a â€œchronic diseaseâ€ by World Obesity Federation. Read to find out more.

Is COVID 19 the same as SARS

There were several speculations whether COVID-19 was the same as SARS or MERS. While there are similarities between the illnesses, the differences are more substantial.

Best way to stay protected, Wear Masks